Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.
Identifieur interne : 000447 ( Main/Exploration ); précédent : 000446; suivant : 000448Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.
Auteurs : Elizabeth R. Mann [Royaume-Uni] ; Madhvi Menon [Royaume-Uni] ; Sean Blandin Knight [Royaume-Uni] ; Joanne E. Konkel [Royaume-Uni] ; Christopher Jagger [Royaume-Uni] ; Tovah N. Shaw [Royaume-Uni] ; Siddharth Krishnan [Royaume-Uni] ; Magnus Rattray [Royaume-Uni] ; Andrew Ustianowski [Royaume-Uni] ; Nawar Diar Bakerly [Royaume-Uni] ; Paul Dark [Royaume-Uni] ; Graham Lord [Royaume-Uni] ; Angela Simpson [Royaume-Uni] ; Timothy Felton [Royaume-Uni] ; Ling-Pei Ho [Royaume-Uni] ; Marc Feldmann [Royaume-Uni] ; John R. Grainger [Royaume-Uni] ; Tracy Hussell [Royaume-Uni]Source :
- Science immunology [ 2470-9468 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Antigène KI-67 (immunologie), Antigène KI-67 (métabolisme), Betacoronavirus (immunologie), Cyclooxygenase 2 (immunologie), Cyclooxygenase 2 (métabolisme), Femelle (MeSH), Humains (MeSH), Immunité innée (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (immunologie), Infections à coronavirus (sang), Infections à coronavirus (épidémiologie), Interactions hôte-microbes (immunologie), Marqueurs biologiques (sang), Monocytes (immunologie), Monocytes (métabolisme), Mâle (MeSH), Médiateurs de l'inflammation (immunologie), Médiateurs de l'inflammation (sang), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (immunologie), Pneumopathie virale (sang), Pneumopathie virale (épidémiologie), Royaume-Uni (épidémiologie), Sujet âgé (MeSH), Études longitudinales (MeSH), Études prospectives (MeSH), Évolution de la maladie (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- immunologie : Antigène KI-67, Betacoronavirus, Cyclooxygenase 2, Infections à coronavirus, Interactions hôte-microbes, Monocytes, Médiateurs de l'inflammation, Pneumopathie virale.
- métabolisme : Antigène KI-67, Cyclooxygenase 2, Monocytes.
- sang : Infections à coronavirus, Marqueurs biologiques, Médiateurs de l'inflammation, Pneumopathie virale.
- épidémiologie : Infections à coronavirus, Pneumopathie virale, Royaume-Uni.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Immunité innée, Indice de gravité de la maladie, Mâle, Pandémies, Sujet âgé, Études longitudinales, Études prospectives, Évolution de la maladie.
- Wicri :
- geographic : Royaume-Uni.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (immunology), Biomarkers (blood), Coronavirus Infections (blood), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (immunology), Cyclooxygenase 2 (immunology), Cyclooxygenase 2 (metabolism), Disease Progression (MeSH), Female (MeSH), Host Microbial Interactions (immunology), Humans (MeSH), Immunity, Innate (MeSH), Inflammation Mediators (blood), Inflammation Mediators (immunology), Ki-67 Antigen (immunology), Ki-67 Antigen (metabolism), Longitudinal Studies (MeSH), Male (MeSH), Middle Aged (MeSH), Monocytes (immunology), Monocytes (metabolism), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (immunology), Prospective Studies (MeSH), Severity of Illness Index (MeSH), United Kingdom (epidemiology).
- MESH :
- chemical , blood : Biomarkers, Inflammation Mediators.
- geographic , epidemiology : United Kingdom.
- blood : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- immunology : Betacoronavirus, Coronavirus Infections, Cyclooxygenase 2, Host Microbial Interactions, Inflammation Mediators, Ki-67 Antigen, Monocytes, Pneumonia, Viral.
- chemical , metabolism : Cyclooxygenase 2, Ki-67 Antigen, Monocytes.
- Adult, Aged, Disease Progression, Female, Humans, Immunity, Innate, Longitudinal Studies, Male, Middle Aged, Pandemics, Prospective Studies, Severity of Illness Index.
Abstract
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells (PBMCs) of hospitalized patients during the peak of the COVID-19 pandemic in the UK. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1 and IP-10, and most strikingly, modulation of CD14+ monocyte phenotype and function. Modified features of CD14+ monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, as well as enhanced expression of the cell cycle marker Ki-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. These findings identify previously unappreciated alterations in the innate immune compartment of COVID-19 patients and lend support to the idea that therapeutic strategies targeting release of myeloid cells from bone marrow should be considered in this disease. Moreover, they demonstrate that features of an exaggerated immune response are present early after hospital admission suggesting immune-modulating therapies would be most beneficial at early timepoints.
DOI: 10.1126/sciimmunol.abd6197
PubMed: 32943497
Affiliations:
- Royaume-Uni
- Angleterre, Grand Manchester, Oxfordshire
- Manchester, Oxford
- Université d'Oxford, Université de Manchester
Links toward previous steps (curation, corpus...)
Le document en format XML
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Konkel</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Jagger, Christopher" sort="Jagger, Christopher" uniqKey="Jagger C" first="Christopher" last="Jagger">Christopher Jagger</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Shaw, Tovah N" sort="Shaw, Tovah N" uniqKey="Shaw T" first="Tovah N" last="Shaw">Tovah N. Shaw</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Krishnan, Siddharth" sort="Krishnan, Siddharth" uniqKey="Krishnan S" first="Siddharth" last="Krishnan">Siddharth Krishnan</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Rattray, Magnus" sort="Rattray, Magnus" uniqKey="Rattray M" first="Magnus" last="Rattray">Magnus Rattray</name><affiliation wicri:level="4"><nlm:affiliation>Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ustianowski, Andrew" sort="Ustianowski, Andrew" uniqKey="Ustianowski A" first="Andrew" last="Ustianowski">Andrew Ustianowski</name><affiliation wicri:level="3"><nlm:affiliation>Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Bakerly, Nawar Diar" sort="Bakerly, Nawar Diar" uniqKey="Bakerly N" first="Nawar Diar" last="Bakerly">Nawar Diar Bakerly</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD</wicri:regionArea><wicri:noRegion>M6 8HD</wicri:noRegion></affiliation></author><author><name sortKey="Dark, Paul" sort="Dark, Paul" uniqKey="Dark P" first="Paul" last="Dark">Paul Dark</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD</wicri:regionArea><wicri:noRegion>M6 8HD</wicri:noRegion></affiliation></author><author><name sortKey="Lord, Graham" sort="Lord, Graham" uniqKey="Lord G" first="Graham" last="Lord">Graham Lord</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Simpson, Angela" sort="Simpson, Angela" uniqKey="Simpson A" first="Angela" last="Simpson">Angela Simpson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital</wicri:regionArea><wicri:noRegion>Wythenshawe Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Felton, Timothy" sort="Felton, Timothy" uniqKey="Felton T" first="Timothy" last="Felton">Timothy Felton</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital</wicri:regionArea><wicri:noRegion>Wythenshawe Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name><affiliation wicri:level="4"><nlm:affiliation>MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Feldmann, Marc" sort="Feldmann, Marc" uniqKey="Feldmann M" first="Marc" last="Feldmann">Marc Feldmann</name><affiliation wicri:level="1"><nlm:affiliation>Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford, OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford, OX3 7LD</wicri:regionArea><wicri:noRegion>OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Grainger, John R" sort="Grainger, John R" uniqKey="Grainger J" first="John R" last="Grainger">John R. Grainger</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Hussell, Tracy" sort="Hussell, Tracy" uniqKey="Hussell T" first="Tracy" last="Hussell">Tracy Hussell</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32943497</idno><idno type="pmid">32943497</idno><idno type="doi">10.1126/sciimmunol.abd6197</idno><idno type="wicri:Area/Main/Corpus">000171</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000171</idno><idno type="wicri:Area/Main/Curation">000171</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000171</idno><idno type="wicri:Area/Main/Exploration">000171</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.</title><author><name sortKey="Mann, Elizabeth R" sort="Mann, Elizabeth R" uniqKey="Mann E" first="Elizabeth R" last="Mann">Elizabeth R. Mann</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 5th Floor St. Mary's Hospital, Oxford Road, Manchester M13 9WL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 5th Floor St. Mary's Hospital, Oxford Road, Manchester M13 9WL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Menon, Madhvi" sort="Menon, Madhvi" uniqKey="Menon M" first="Madhvi" last="Menon">Madhvi Menon</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Knight, Sean Blandin" sort="Knight, Sean Blandin" uniqKey="Knight S" first="Sean Blandin" last="Knight">Sean Blandin Knight</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD</wicri:regionArea><wicri:noRegion>M6 8HD</wicri:noRegion></affiliation></author><author><name sortKey="Konkel, Joanne E" sort="Konkel, Joanne E" uniqKey="Konkel J" first="Joanne E" last="Konkel">Joanne E. Konkel</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Jagger, Christopher" sort="Jagger, Christopher" uniqKey="Jagger C" first="Christopher" last="Jagger">Christopher Jagger</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Shaw, Tovah N" sort="Shaw, Tovah N" uniqKey="Shaw T" first="Tovah N" last="Shaw">Tovah N. Shaw</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Krishnan, Siddharth" sort="Krishnan, Siddharth" uniqKey="Krishnan S" first="Siddharth" last="Krishnan">Siddharth Krishnan</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Rattray, Magnus" sort="Rattray, Magnus" uniqKey="Rattray M" first="Magnus" last="Rattray">Magnus Rattray</name><affiliation wicri:level="4"><nlm:affiliation>Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ustianowski, Andrew" sort="Ustianowski, Andrew" uniqKey="Ustianowski A" first="Andrew" last="Ustianowski">Andrew Ustianowski</name><affiliation wicri:level="3"><nlm:affiliation>Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Bakerly, Nawar Diar" sort="Bakerly, Nawar Diar" uniqKey="Bakerly N" first="Nawar Diar" last="Bakerly">Nawar Diar Bakerly</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD</wicri:regionArea><wicri:noRegion>M6 8HD</wicri:noRegion></affiliation></author><author><name sortKey="Dark, Paul" sort="Dark, Paul" uniqKey="Dark P" first="Paul" last="Dark">Paul Dark</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD</wicri:regionArea><wicri:noRegion>M6 8HD</wicri:noRegion></affiliation></author><author><name sortKey="Lord, Graham" sort="Lord, Graham" uniqKey="Lord G" first="Graham" last="Lord">Graham Lord</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Simpson, Angela" sort="Simpson, Angela" uniqKey="Simpson A" first="Angela" last="Simpson">Angela Simpson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital</wicri:regionArea><wicri:noRegion>Wythenshawe Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Felton, Timothy" sort="Felton, Timothy" uniqKey="Felton T" first="Timothy" last="Felton">Timothy Felton</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital</wicri:regionArea><wicri:noRegion>Wythenshawe Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name><affiliation wicri:level="4"><nlm:affiliation>MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Feldmann, Marc" sort="Feldmann, Marc" uniqKey="Feldmann M" first="Marc" last="Feldmann">Marc Feldmann</name><affiliation wicri:level="1"><nlm:affiliation>Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford, OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford, OX3 7LD</wicri:regionArea><wicri:noRegion>OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Grainger, John R" sort="Grainger, John R" uniqKey="Grainger J" first="John R" last="Grainger">John R. Grainger</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Hussell, Tracy" sort="Hussell, Tracy" uniqKey="Hussell T" first="Tracy" last="Hussell">Tracy Hussell</name><affiliation wicri:level="4"><nlm:affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author></analytic><series><title level="j">Science immunology</title><idno type="eISSN">2470-9468</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (immunology)</term><term>Biomarkers (blood)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (immunology)</term><term>Cyclooxygenase 2 (immunology)</term><term>Cyclooxygenase 2 (metabolism)</term><term>Disease Progression (MeSH)</term><term>Female (MeSH)</term><term>Host Microbial Interactions (immunology)</term><term>Humans (MeSH)</term><term>Immunity, Innate (MeSH)</term><term>Inflammation Mediators (blood)</term><term>Inflammation Mediators (immunology)</term><term>Ki-67 Antigen (immunology)</term><term>Ki-67 Antigen (metabolism)</term><term>Longitudinal Studies (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Monocytes (immunology)</term><term>Monocytes (metabolism)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (immunology)</term><term>Prospective Studies (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>United Kingdom (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antigène KI-67 (immunologie)</term><term>Antigène KI-67 (métabolisme)</term><term>Betacoronavirus (immunologie)</term><term>Cyclooxygenase 2 (immunologie)</term><term>Cyclooxygenase 2 (métabolisme)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Immunité innée (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (épidémiologie)</term><term>Interactions hôte-microbes (immunologie)</term><term>Marqueurs biologiques (sang)</term><term>Monocytes (immunologie)</term><term>Monocytes (métabolisme)</term><term>Mâle (MeSH)</term><term>Médiateurs de l'inflammation (immunologie)</term><term>Médiateurs de l'inflammation (sang)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (immunologie)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (épidémiologie)</term><term>Royaume-Uni (épidémiologie)</term><term>Sujet âgé (MeSH)</term><term>Études longitudinales (MeSH)</term><term>Études prospectives (MeSH)</term><term>Évolution de la maladie (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United Kingdom</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigène KI-67</term><term>Betacoronavirus</term><term>Cyclooxygenase 2</term><term>Infections à coronavirus</term><term>Interactions hôte-microbes</term><term>Monocytes</term><term>Médiateurs de l'inflammation</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus Infections</term><term>Cyclooxygenase 2</term><term>Host Microbial Interactions</term><term>Inflammation Mediators</term><term>Ki-67 Antigen</term><term>Monocytes</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term><term>Ki-67 Antigen</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigène KI-67</term><term>Cyclooxygenase 2</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Infections à coronavirus</term><term>Marqueurs biologiques</term><term>Médiateurs de l'inflammation</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Royaume-Uni</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Immunity, Innate</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Immunité innée</term><term>Indice de gravité de la maladie</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Études longitudinales</term><term>Études prospectives</term><term>Évolution de la maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Royaume-Uni</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells (PBMCs) of hospitalized patients during the peak of the COVID-19 pandemic in the UK. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1 and IP-10, and most strikingly, modulation of CD14<sup>+</sup> monocyte phenotype and function. Modified features of CD14<sup>+</sup> monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, as well as enhanced expression of the cell cycle marker K<sub>i</sub>-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. These findings identify previously unappreciated alterations in the innate immune compartment of COVID-19 patients and lend support to the idea that therapeutic strategies targeting release of myeloid cells from bone marrow should be considered in this disease. Moreover, they demonstrate that features of an exaggerated immune response are present early after hospital admission suggesting immune-modulating therapies would be most beneficial at early timepoints.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32943497</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2470-9468</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>51</Issue><PubDate><Year>2020</Year><Month>09</Month><Day>17</Day></PubDate></JournalIssue><Title>Science immunology</Title><ISOAbbreviation>Sci Immunol</ISOAbbreviation></Journal><ArticleTitle>Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">eabd6197</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1126/sciimmunol.abd6197</ELocationID><Abstract><AbstractText>COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells (PBMCs) of hospitalized patients during the peak of the COVID-19 pandemic in the UK. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1 and IP-10, and most strikingly, modulation of CD14<sup>+</sup> monocyte phenotype and function. Modified features of CD14<sup>+</sup> monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, as well as enhanced expression of the cell cycle marker K<sub>i</sub>-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. These findings identify previously unappreciated alterations in the innate immune compartment of COVID-19 patients and lend support to the idea that therapeutic strategies targeting release of myeloid cells from bone marrow should be considered in this disease. Moreover, they demonstrate that features of an exaggerated immune response are present early after hospital admission suggesting immune-modulating therapies would be most beneficial at early timepoints.</AbstractText><CopyrightInformation>Copyright © 2020, American Association for the Advancement of Science.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Mann</LastName><ForeName>Elizabeth R</ForeName><Initials>ER</Initials><Identifier Source="ORCID">0000-0002-0803-0357</Identifier><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 5th Floor St. Mary's Hospital, Oxford Road, Manchester M13 9WL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Menon</LastName><ForeName>Madhvi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Knight</LastName><ForeName>Sean Blandin</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Konkel</LastName><ForeName>Joanne E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jagger</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-8310-9516</Identifier><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>Tovah N</ForeName><Initials>TN</Initials><Identifier Source="ORCID">0000-0002-8107-2836</Identifier><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krishnan</LastName><ForeName>Siddharth</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-9270-7083</Identifier><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rattray</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-8196-5565</Identifier><AffiliationInfo><Affiliation>Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ustianowski</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bakerly</LastName><ForeName>Nawar Diar</ForeName><Initials>ND</Initials><Identifier Source="ORCID">0000-0003-2102-1997</Identifier><AffiliationInfo><Affiliation>Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dark</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lord</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Felton</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><Identifier Source="ORCID">0000-0001-6868-6633</Identifier><AffiliationInfo><Affiliation>Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Ling-Pei</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>NIHR Respiratory TRC,</CollectiveName></Author><Author ValidYN="Y"><LastName>Feldmann</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford, OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>CIRCO,</CollectiveName></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Grainger</LastName><ForeName>John R</ForeName><Initials>JR</Initials><Identifier Source="ORCID">0000-0002-4052-5923</Identifier><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Hussell</LastName><ForeName>Tracy</ForeName><Initials>T</Initials><Identifier Source="ORCID">0000-0001-7186-6141</Identifier><AffiliationInfo><Affiliation>Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>202865/Z/16/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>106898/A/15/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>20606/Z/17/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sci Immunol</MedlineTA><NlmUniqueID>101688624</NlmUniqueID><ISSNLinking>2470-9468</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019394">Ki-67 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000628856">MKI67 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="C496540">PTGS2 protein, human</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000076662" MajorTopicYN="N">Host Microbial Interactions</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="Y">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019394" MajorTopicYN="N">Ki-67 Antigen</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009000" MajorTopicYN="N">Monocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006113" MajorTopicYN="N" Type="Geographic">United Kingdom</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Horsley</LastName><ForeName>Alex</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harrison</LastName><ForeName>Tim</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Porter</LastName><ForeName>Joanna</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Djukanovic</LastName><ForeName>Ratko</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marciniak</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brightling</LastName><ForeName>Chris</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ho</LastName><ForeName>Ling-Pei</ForeName><Initials>LP</Initials></Investigator><Investigator ValidYN="Y"><LastName>McGarvey</LastName><ForeName>Lorcan</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Davies</LastName><ForeName>Jane</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Rohan</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shuwa</LastName><ForeName>Halima Ali</ForeName><Initials>HA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Avery</LastName><ForeName>Miriam</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Birchall</LastName><ForeName>Katharine</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brand</LastName><ForeName>Oliver</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Charsley</LastName><ForeName>Evelyn</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chenery</LastName><ForeName>Alistair</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chew</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clark</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Connolly</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Connolly</LastName><ForeName>Karen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dawson</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Durrans</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Durrington</LastName><ForeName>Hannah</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Egan</LastName><ForeName>Jasmine</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fox</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Francis</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Franklin</LastName><ForeName>Miriam</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Glasgow</LastName><ForeName>Susannah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Godfrey</LastName><ForeName>Nicola</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gray</LastName><ForeName>Kathryn J</ForeName><Initials>KJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grundy</LastName><ForeName>Seamus</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guerin</LastName><ForeName>Jacinta</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hackney</LastName><ForeName>Pamela</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iqbal</LastName><ForeName>Mudassar</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hayes</LastName><ForeName>Chantelle</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hardy</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harris</LastName><ForeName>Jade</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>John</LastName><ForeName>Anu</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jolly</LastName><ForeName>Bethany</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kästele</LastName><ForeName>Verena</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Khan</LastName><ForeName>Saba</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lindergard</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lui</LastName><ForeName>Sylvia</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lowe</LastName><ForeName>Lesley</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mathioudakis</LastName><ForeName>Alex G</ForeName><Initials>AG</Initials></Investigator><Investigator ValidYN="Y"><LastName>McClure</LastName><ForeName>Flora A</ForeName><Initials>FA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moizer</LastName><ForeName>Clare</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moore</LastName><ForeName>Katrina</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Morgan</LastName><ForeName>David J</ForeName><Initials>DJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moss</LastName><ForeName>Stuart</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baker</LastName><ForeName>Syed Murtuza</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Oliver</LastName><ForeName>Rob</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Padden</LastName><ForeName>Grace</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parkinson</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pearmain</LastName><ForeName>Laurence</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Phuycharoen</LastName><ForeName>Mike</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Saha</LastName><ForeName>Ananya</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Salcman</LastName><ForeName>Barbora</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scott</LastName><ForeName>Nicholas A</ForeName><Initials>NA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sharma</LastName><ForeName>Seema</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shaw</LastName><ForeName>Jane</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shaw</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shepley</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>Lara</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stephan</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stephens</LastName><ForeName>Ruth</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tavernier</LastName><ForeName>Gael</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tudge</LastName><ForeName>Rhys</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wareing</LastName><ForeName>Louis</ForeName><Initials>L</Initials></Investigator><Investigator 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Mann</name></region><name sortKey="Bakerly, Nawar Diar" sort="Bakerly, Nawar Diar" uniqKey="Bakerly N" first="Nawar Diar" last="Bakerly">Nawar Diar Bakerly</name><name sortKey="Dark, Paul" sort="Dark, Paul" uniqKey="Dark P" first="Paul" last="Dark">Paul Dark</name><name sortKey="Feldmann, Marc" sort="Feldmann, Marc" uniqKey="Feldmann M" first="Marc" last="Feldmann">Marc Feldmann</name><name sortKey="Felton, Timothy" sort="Felton, Timothy" uniqKey="Felton T" first="Timothy" last="Felton">Timothy Felton</name><name sortKey="Grainger, John R" sort="Grainger, John R" uniqKey="Grainger J" first="John R" last="Grainger">John R. Grainger</name><name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name><name sortKey="Hussell, Tracy" sort="Hussell, Tracy" uniqKey="Hussell T" first="Tracy" last="Hussell">Tracy Hussell</name><name sortKey="Jagger, Christopher" sort="Jagger, Christopher" uniqKey="Jagger C" first="Christopher" last="Jagger">Christopher Jagger</name><name sortKey="Knight, Sean Blandin" sort="Knight, Sean Blandin" uniqKey="Knight S" first="Sean Blandin" last="Knight">Sean Blandin Knight</name><name sortKey="Knight, Sean Blandin" sort="Knight, Sean Blandin" uniqKey="Knight S" first="Sean Blandin" last="Knight">Sean Blandin Knight</name><name sortKey="Konkel, Joanne E" sort="Konkel, Joanne E" uniqKey="Konkel J" first="Joanne E" last="Konkel">Joanne E. Konkel</name><name sortKey="Krishnan, Siddharth" sort="Krishnan, Siddharth" uniqKey="Krishnan S" first="Siddharth" last="Krishnan">Siddharth Krishnan</name><name sortKey="Lord, Graham" sort="Lord, Graham" uniqKey="Lord G" first="Graham" last="Lord">Graham Lord</name><name sortKey="Mann, Elizabeth R" sort="Mann, Elizabeth R" uniqKey="Mann E" first="Elizabeth R" last="Mann">Elizabeth R. Mann</name><name sortKey="Menon, Madhvi" sort="Menon, Madhvi" uniqKey="Menon M" first="Madhvi" last="Menon">Madhvi Menon</name><name sortKey="Rattray, Magnus" sort="Rattray, Magnus" uniqKey="Rattray M" first="Magnus" last="Rattray">Magnus Rattray</name><name sortKey="Shaw, Tovah N" sort="Shaw, Tovah N" uniqKey="Shaw T" first="Tovah N" last="Shaw">Tovah N. Shaw</name><name sortKey="Simpson, Angela" sort="Simpson, Angela" uniqKey="Simpson A" first="Angela" last="Simpson">Angela Simpson</name><name sortKey="Ustianowski, Andrew" sort="Ustianowski, Andrew" uniqKey="Ustianowski A" first="Andrew" last="Ustianowski">Andrew Ustianowski</name><name sortKey="Ustianowski, Andrew" sort="Ustianowski, Andrew" uniqKey="Ustianowski A" first="Andrew" last="Ustianowski">Andrew Ustianowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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{{Explor lien
|wiki= Sante
|area= CovidSeniorV1
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|type= RBID
|clé= pubmed:32943497
|texte= Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.
}}
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